Our lab uses a multimodal approach (EEG, fMRI, experience sampling, laboratory-based experiments, and clinical interviewing) to investigate the etiology and pathophysiology of depression in adolescents, as well as the mechanisms of change in psychotherapeutic and pharmacological treatments for depression. Ongoing studies are investigating the predictors and mechanisms of change in an app-based mindfulness training, as well as examining the predictors of depression onset in at-risk youth.